把猪作为慢性疾病的研究样本 或许有助于提高药品研发成功率

　　GLOBAL - Scientists may be able to minimise the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of researchers.In a study, researchers found that pigs, which have gut bacterial profiles and immune systems similar to humans, also maintain two distinct colonic stem cell populations - ASCL-2 and BMI-1. Mice lack colonic BMI-1 stem cells that play a critical role in how colon cancer forms - or carcinogenesis - and how material passes through the cell lining of the intestinal wall - or gut permeability.

　　根据一个国际研究团队的研究显示，科学家在涉及与高热量饮食有关的疾病研究时，如果把猪作为测试治疗实验中的样本，或许能够减小药品的研发失败率，比如大肠癌和二型糖尿病。根据研究，科学家发现，猪拥有和人类类似的肠道菌群以及免疫系统，它们也有两个截然不同的结肠干细胞群ASCL-2与BMI-1。老鼠就缺乏肠道干细胞BMI-1，而肠道干细胞在肠道癌的形成过程中发挥着重要的作用，它可以解释物质是如何通过肠道壁衬里，解释肠道渗透性。